Job ID: 289590774  |  Last Updated: 6/25/2018

Computational Biologist - Single Cell Biology

The Jackson Labratory
Farmington, CT
Applicant Contact
Mandi Marcino
Accepts J-1 Visas

Job Description

The Computational Biologist, working with limited supervision and reporting to the Director of the Single Cell Biology Laboratory, will participate in the collaborative single cell biology program aligned with institutional strategy and direction and make leading contributions to the cutting-edge projects at The Jackson Laboratory. They will be tightly integrated with the wet lab biologists within the Single Cell Biology Laboratory and have direct access to, and guidance from, the JAX Computational Sciences team. The successful candidate will be intimately involved in all single cell projects initiated by JAX faculty and other divisions across the JAX organization in addition to collaborating with clinical and industry partners. Projects will span a diverse array of biomedical disciplines such as cancer biology, ageing, immunology, infectious diseases, metabolism, neural disorders, muscular disorders, stem cell and developmental biology but have a particular emphasis on developing precision medicine applications applied to cancer. Over the past 2 years the Single Cell Biology Laboratory has generated over 2 million single cell transcirptomes and is actively engaged in imaging mass cytometry in addition to numerous other data types to visualize biology at single cell resolution.

While the successful candidate will have primary responsibility for providing a robust and innovative computational pipeline for single cell biology workflows, the ideal candidate will have a very strong computational skill set and, while not essential, have some wet lab cell/molecular biology experience. It is expected the candidate will train current single cell laboratory wet lab scientists in computational methods and in turn be involved in the design of wet lab single cell biology protocol development and experimentation. The candidate will additionally be expected to drive and/or contribute to publications and grant applications.

The position is located in Connecticut. They are expected to sustain collaborations with The JAX research staff and faculty on both the Farmington, CT and Bar Harbor, ME campuses and to visit Bar Harbor on an occasional basis.

Key Responsibilities:
Design, develop and operate computational pipelines for analysis of high throughput single cell data.
Provide computational support for all single cell biology projects.
Participate in data processing, programming and algorithm development.
Participate in evaluation of new technology platforms, assays and software.

Ph.D. or MS in a relevant discipline with 2+ years experience in Bioinformatics or Computational Biology. Exceptional candidates may be considered without experience.
Some knowledge of mammalian biology, preferable through wet bench experience.
Aptitude to work in a team environment.
Programming experience in Python and R, with additional experience in Java, C/C++, and Perl and asset.
Proficiency in UNIX scripting and various bioinformatics tools and databases.
Experience in analysis of large multi-dimensional genomic datasets.
Experience in developing computational pipelines and algorithms for genomic/transcriptomic research and/or multidimensional cytometry data.
Deep knowledge on sequencing technologies.

About us:
The Jackson Laboratory ( is a nonprofit biomedical research institute with over 1,800 employees across three campuses nationwide. Our mission is to discover precise genomic solutions for human disease, and to empower the global biomedical community in the shared quest to improve human health. JAX's research institute in Connecticut, The Jackson Laboratory for Genomic Medicine (JAX-GM), is transforming medicine by improving patient care, lowering costs, and increasing life span and health span. JAX-GMs research focuses on the complex genetic causes of disease, and on the development of genomic solutions tailored to each person's unique genetic makeup.

JAX-GM sits on a 17-acre site on the campus of the University of Connecticut Health Center. The 183,500-square-foot facility opened in the fall of 2014. Now, it houses over 300 biomedical researchers, technicians and support staff in state-of-the-art computing facilities and laboratories. Our employees work in a collaborative, value-driven, and team-based environment where the focus is on advancing science and improving patients lives.
JAX-GM resides in the scenic town of Farmington, in the states capitol region. The Hartford region, which offers some of the best public schools in the country, is made up of both bigger cities and smaller, charming historic New England towns. JAX-GM is also geographically located within 2 hours of Boston and New York and is close to multiple transportation systems including bus lines, highways, railroads and international airports.

Our Values:
INTEGRITY - Courage and commitment to do what is right

PEOPLE - Inspiring our people to enhance the health of all

ONE TEAM - Unified by our promise to transform medicine and science

EXCELLENCE - Achieving world-class results

INNOVATION - Leading with discovery and creative solutions

STEWARDSHIP - Caring for and enhancing the resources entrusted to us

What do we have to offer?
JAX offers a dynamic and supportive work environment, competitive salaries and a comprehensive benefits package including a medical plan, outstanding retirement plan, generous paid time off and tuition reimbursement. JAX offers an MBA program, a fitness center with an award winning wellness program, and a fully operational primary care facility available to employees and their families.
Most importantly, every position contributes to JAXs mission of discovering precise genomic solutions for human disease and empowering the global biomedical community in our shared quest to improve human health.

The Jackson Laboratory provides equal employment opportunities to all employees and applicants for employment in all job classifications without regard to race, color, religion, age, mental disability, physical disability, medical condition, gender, sexual orientation, genetic information, ancestry, marital status, national origin, veteran status, and other classifications protected by applicable state and local non-discrimination laws.

Learn more about at opportunities at JAX at

Job Location
Farmington, Connecticut, United States
Position Type

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